Frequently Asked Questions: Methylated Prenatal Vitamins

Methylated prenatal vitamins contain folate and other B vitamins in their active, bioavailable forms (like L-methylfolate) rather than synthetic versions like folic acid. This means your body can use these nutrients immediately without needing to convert them first.

Regular prenatal vitamins typically use synthetic folic acid, which requires a multi-step enzyme process to become usable by the body. Methylated prenatals bypass this conversion process, delivering the nutrient in a form your cells can absorb and utilize right away

While they are safe for most people, they are specifically recommended for individuals with the MTHFR gene mutation, which impairs the body's ability to process synthetic folic acid. Anyone looking to maximize nutrient absorption during pregnancy may also benefit from choosing a methylated option.

Methylated folate (5-MTHF) is the natural form of vitamin B9 found in food and in human blood, making it easier for the body to absorb. Because up to 40-60% of the population has a genetic variation that makes processing synthetic folic acid difficult, the methylated form ensures consistent nutrient levels.

Some women report that methylated B vitamins, particularly methylated B6 and B12, are gentler on the stomach and may help reduce nausea compared to synthetic versions. However, individual responses vary, so it is best to consult your healthcare provider.

Yes, you can generally switch to a methylated prenatal vitamin at any stage of pregnancy. It is always a good idea to discuss any supplement changes with your doctor or midwife first.

They often have a higher price point than standard drugstore prenatals because the raw ingredients (active folate and methylated B vitamins) are more expensive to source and manufacture. However, we have priced our methylated prenatal so that it is cost effective for use before, during, and after pregnancy.